Valbade 450

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ValbadeTM 450

Each Tablet contains Valganciclovir Hydrochloride, is an L-Valyl ester (prodrug) of ganciclovir the exist as a mixture of two diastereomers.

Mechanism of Action

  • Ganciclovir (9[(1,3, -dihydroxy-2-propoxy) methyl] guanine, or DHPG) is an acyclic analogue of the nucleoside guanosine.
  • The drug is converted intracellularly to ganciclovir 5′-monophosphate by a viral kinase, which is encoded by the cytomegalovirus (CMV) gene UL97 during infection.
  • Subsequently, cellular kinases catalyse the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells.
  • Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases.
  • In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route.


As directed by the physician.

  • Prevention of cytomegalovirus (CMV) disease in kidney, Liver & Heart, kidney-pancreas transplant patients at high risk.
  • Congenital CMV
  • Cytomegalovirus (CMV) retinitis in patients with AIDS
Adverse effects:
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Seizures