CrolimusTM
Available as: 1mg, 2mg, 0.5mg, 0.25mg
Each capsule contains Tacrolimus, is an immunosuppressant.
In organ transplant patients, it works by suppressing your body’s immune response helping your body to accept the new organ as if it were your own. In allergic eye disease, it works by decreasing the production of chemicals (eg. histamine) that cause allergic eye symptoms such as inflammation (redness and swelling).
Mechanism of Action
- CrolimusTM binds to an intracellular receptor and subsequently binds to calcineurin and inhibits the calcineurin pathway that stimulates the nuclear factor, NFAT.
- The action resembles that of cyclosporine (both drugs are calcineurin inhibitors), although the cellular receptors differ.
- By inhibiting the action of NFAT, tacrolimus decreases synthesis of inflammatory cytokines. In particular, synthesis of interleukin-2 (IL-2) is inhibited, which results in decreased activation of T-lymphocytes.
- CrolimusTM is 10-100 times more potent than cyclosporine.
- CrolimusTM inhibits release of mast cell and basophil mediators and decreases inflammatory mediator expression.
Dosage:
As directed by the physician.
Indication:
- Renal Transplantation
- Liver transplant
- Nephrotic syndrome
Adverse Effects:
- Nephrotoxicity
- Neutropenia