ValbadeTM 450
Each Tablet contains Valganciclovir Hydrochloride, is an L-Valyl ester (prodrug) of ganciclovir the exist as a mixture of two diastereomers.
Mechanism of Action
- Ganciclovir (9– [(1,3, -dihydroxy-2-propoxy) methyl] guanine, or DHPG) is an acyclic analogue of the nucleoside guanosine.
- The drug is converted intracellularly to ganciclovir 5′-monophosphate by a viral kinase, which is encoded by the cytomegalovirus (CMV) gene UL97 during infection.
- Subsequently, cellular kinases catalyse the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells.
- Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases.
- In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route.
Dosage:
As directed by the physician.
Indications:
- Prevention of cytomegalovirus (CMV) disease in kidney, Liver & Heart, kidney-pancreas transplant patients at high risk.
- Congenital CMV
- Cytomegalovirus (CMV) retinitis in patients with AIDS
Adverse effects:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Seizures